When was depakote invented

Hepatic failure resulting in fatalities has occurred in patients receiving Depakote, usually during the first six months of treatment.

Also known as valproate, the drug may produce malformations in the fetus of women taking Depakote during pregnancy. Benefits of using Depakote and Depakote ER in migraine treatment should be weighed against risk of injury to the fetus in women of childbearing potential.

Cases of life-threatening pancreatitis, some rapidly progressing to death, have been reported in both adults and children receiving valproate. Because bipolar disorder manic-depressive illness is a common and highly recurrent disorder requiring lifelong treatment, many women of childbearing age are maintained on mood stabilizers such as lithium and the anticonvulsant Depakote valproic acid. Both drugs are teratogenic, so women with bipolar disease have typically been counseled to defer childbearing or abruptly stop their medications when they get pregnant.

The study by Bowden et al. The field of bipolar disorders currently appears much wider and more heterogeneous than has long been held. Current therapeutic strategy is dominated by thymoregulators. In such long-term therapy where poor compliance constitutes a risk factor for treatment failure, use of valproate valpromide, divalproate has the twin advantage of being easy to manage and well tolerated in the long-term.

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Health insurance that you or a family member obtained through an employer or purchased privately. The DEPAKOTE Savings Card is not available to individuals who are paying cash for their prescription or who are receiving prescription reimbursement under a state or federally funded insurance program.

This rebate form is not available to individuals who are paying cash for their prescription or who are receiving prescription reimbursement under a state or federally funded insurance program. Important Safety Information Prescribing Information. Home About Depakote. About Depakote.